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Charles Gawad, M.D. PhD.
Associate Professor
Stanford Medicine
Department of Pediatrics

240 Pasteur Dr
RM2200 - BMI Building
Palo Alto, CA 94304

Email: cgawad@stanford.edu

Publications

2022 Science Advances
Simultaneous monitoring of disease and microbe dynamics through plasma DNA sequencing in pediatric patients with acute lymphoblastic leukemia
Barsan V, Xia Y, Klein D, Gonzalez-Pena V, Youssef S, Inaba Y, Mahmud O, Natarajan S, Agarwal V, Pang Y, Autry R, Pui CH, Inaba H, Evans W, Gawad C.

2021 Clinical & Experimental Metastasis
Bringing precision oncology to cellular resolution with single-cell genomics
Xia Y, Gawad C,

2021 Proceedings of the National Academy of Sciences of the United States of America
Accurate genomic variant detection in single cells with primary template-directed amplification
Gonzalez-Pena V, Natarajan S, Xia Y, Klein D, Carter R, Pang Y, Shaner B, Annu K, Putnam D, Chen W, Connelly J, Pruett-Miller S, Chen X, Easton J, Gawad C,

2020 JAMA Oncology
Evaluation of Plasma Microbial Cell-Free DNA Sequencing to Predict Bloodstream Infection in Pediatric Patients With Relapsed or Refractory Cancer
Goggin KP, Gonzalez-Pena V, Inaba Y, Allison KJ, Hong DK, Ahmed AA, Hollemon D, Natarajan S, Mahmud O, Kuenzinger W, Youssef S, Brenner A, Maron G, Choi J, Rubnitz JE, Sun Y, Tang L, Wolf J, Gawad C,

2020 Nature Cancer
Integrative genomic analyses reveal mechanisms of glucocorticoid resistance in acute lymphoblastic leukemia
Autry RJ, Paugh SW, Carter R, Shi L, Liu J, Ferguson DC, Lau CE, Bonten EJ, Yang W, McCorkle JR, Beard JA, Panetta JC, Diedrich JD, Crews KR, Pei D, Coke CJ, Natarajan S, Khatamian A, Karol SE, Lopez-Lopez E, Diouf B, Smith C, Gocho Y, Hagiwara K, Roberts KG, Pounds S, Kornblau SM, Stock W, Paietta EM, Litzow MR, Inaba H, Mullighan CG, Jeha S, Pui CH, Cheng C, Savic D, Yu J, Gawad C, Relling MV, Yang JJ, Evans WE,

2019 Nature
Resolving medulloblastoma cellular architecture by single-cell genomics
Hovestadt V, Smith KS, Bihannic L, Filbin MG, Shaw ML, Baumgartner A, DeWitt JC, Groves A, Mayr L, Weisman HR, Richman AR, Shore ME, Goumnerova L, Rosencrance C, Carter RA, Phoenix TN, Hadley JL, Tong Y, Houston J, Ashmun RA, DeCuypere M, Sharma T, Flasch D, Silkov A, Ligon KL, Pomeroy SL, Rivera MN, Rozenblatt-Rosen O, Rusert JM, Wechsler-Reya RJ, Li XN, Peyrl A, Gojo J, Kirchhofer D, Lötsch D, Czech T, Dorfer C, Haberler C, Geyeregger R, Halfmann A, Gawad C, Easton J, Pfister SM, Regev A, Gajjar A, Orr BA, Slavc I, Robinson GW, Bernstein BE, Suvà ML, Northcott PA,

2019 BMC Medical Genomics
Single-cell RNA sequencing reveals the impact of chromosomal instability on glioblastoma cancer stem cells
Zhao Y, Carter R, Natarajan S, Varn FS, Compton DA, Gawad C, Cheng C, Godek KM,

2019 Methods in Molecular Biology (Clifton, N.J.)
Sequencing the Genomes of Single Cells
Gonzalez-Pena V, Gawad C,

2018 Nature Communications
Murine hematopoietic stem cell activity is derived from pre-circulation embryos but not yolk sacs
Ganuza M, Chabot A, Tang X, Bi W, Natarajan S, Carter R, Gawad C, Kang G, Cheng Y, McKinney-Freeman S,

2018 Cell
LC3-Associated Phagocytosis in Myeloid Cells Promotes Tumor Immune Tolerance
Cunha LD, Yang M, Carter R, Guy C, Harris L, Crawford JC, Quarato G, Boada-Romero E, Kalkavan H, Johnson MDL, Natarajan S, Turnis ME, Finkelstein D, Opferman JT, Gawad C, Green DR,

2018 Current Biology
A Single-Cell Transcriptional Atlas of the Developing Murine Cerebellum
Carter RA, Bihannic L, Rosencrance C, Hadley JL, Tong Y, Phoenix TN, Natarajan S, Easton J, Northcott PA, Gawad C,

2018 PLoS Genetics
High-resolution transcriptional dissection of in vivo Atoh1-mediated hair cell conversion in mature cochleae identifies Isl1 as a co-reprogramming factor
Yamashita T, Zheng F, Finkelstein D, Kellard Z, Carter R, Rosencrance CD, Sugino K, Easton J, Gawad C, Zuo J,

2018 Blood
Measurable residual disease detection by high-throughput sequencing improves risk stratification for pediatric B-ALL
Wood B, Wu D, Crossley B, Dai Y, Williamson D, Gawad C, Borowitz MJ, Devidas M, Maloney KW, Larsen E, Winick N, Raetz E, Carroll WL, Hunger SP, Loh ML, Robins H, Kirsch I,

2018 Nature
Pan-cancer genome and transcriptome analyses of 1,699 paediatric leukaemias and solid tumours
Ma X, Liu Y, Liu Y, Alexandrov LB, Edmonson MN, Gawad C, Zhou X, Li Y, Rusch MC, Easton J, Huether R, Gonzalez-Pena V, Wilkinson MR, Hermida LC, Davis S, Sioson E, Pounds S, Cao X, Ries RE, Wang Z, Chen X, Dong L, Diskin SJ, Smith MA, Guidry Auvil JM, Meltzer PS, Lau CC, Perlman EJ, Maris JM, Meshinchi S, Hunger SP, Gerhard DS, Zhang J,

2017 BMC Genomics
Genome-wide segregation of single nucleotide and structural variants into single cancer cells
Easton J, Gonzalez-Pena V, Yergeau D, Ma X, Gawad C,

2016 PloS One
Dynamic ASXL1 Exon Skipping and Alternative Circular Splicing in Single Human Cells
Koh W, Gonzalez V, Natarajan S, Carter R, Brown PO, Gawad C,

2016 Proceedings of the National Academy of Sciences of the United States of America
Early somatic mosaicism is a rare cause of long-QT syndrome
Priest JR, Gawad C, Kahlig KM, Yu JK, O'Hara T, Boyle PM, Rajamani S, Clark MJ, Garcia ST, Ceresnak S, Harris J, Boyle S, Dewey FE, Malloy-Walton L, Dunn K, Grove M, Perez MV, Neff NF, Chen R, Maeda K, Dubin A, Belardinelli L, West J, Antolik C, Macaya D, Quertermous T, Trayanova NA, Quake SR, Ashley EA,

2016 Nature Reviews Genetics
Single-cell genome sequencing: current state of the science
Gawad C, Koh W, Quake SR,

2014 Proceedings of the National Academy of Sciences of the United States of America
Dissecting the clonal origins of childhood acute lymphoblastic leukemia by single-cell genomics
Gawad C, Koh W, Quake SR,

2014 PloS One
A quantitative comparison of single-cell whole genome amplification methods
de Bourcy CF, De Vlaminck I, Kanbar JN, Wang J, Gawad C, Quake SR,

2014 Proceedings of the National Academy of Sciences of the United States of America
Noninvasive in vivo monitoring of tissue-specific global gene expression in humans
Koh W, Pan W, Gawad C, Fan HC, Kerchner GA, Wyss-Coray T, Blumenfeld YJ, El-Sayed YY, Quake SR,

2012 Blood
Massive evolution of the immunoglobulin heavy chain locus in children with B precursor acute lymphoblastic leukemia
Gawad C, Pepin F, Carlton VE, Klinger M, Logan AC, Miklos DB, Faham M, Dahl G, Lacayo N,

2012 PloS One
Circular RNAs are the predominant transcript isoform from hundreds of human genes in diverse cell types
Salzman J, Gawad C, Wang PL, Lacayo N, Brown PO,

2005 American Journal of Pharmacogenomics
Towards molecular medicine: a case for a biological periodic table
Gawad C,